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Author contributions RAlg: Conceptualization, Funding acquisition, Investigation, Supervision, Writing original draft, Writing review & editing

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Some studies suggest that prolonged or excessive mTOR inhibition may impair muscle protein synthesis and potentially exacerbate sarcopenia in older adults, highlighting a possible trade-off between metabolic benefits and preservation of lean massan area requiring further investigation [28]

These effects are caused by boosting L-arginine and NO production, leading to enhanced vasodilation, improved endothelial function, and increased muscle blood flow and oxygenation