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Main pathway: G-actin sequestration Native T4 binds monomeric G-actin with a dissociation constant (KD) of approximately 1 M, controlling the pool of free actin available for polymerization into F-actin (actin filaments)

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Conversely, IGF-1 acts to provide an inhibitory feedback signal on GH secretion in the hypothalamus by stimulating somatostatin production in the pituitary [8991]

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