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376,377 Koffler et al

Comparative evaluation of the hepatoprotective, antioxidant and choleretic activity of flavonoid drugs

Excessive ROS can boost the expression of pro-inflammatory cytokines including IL-1, TNF-, IL-6, and COX-2 to regulate the inflammatory response [216, 217], as well as make the MMPs/TIMPs ratio imbalanced by activating MMPs and decreasing TIMP production, decompressing ECM [218]

Despite the lack of consistent study design, the authors concluded that there is little or no evidence to support the hypothesis that proinflammatory circulating cytokines are raised in CFS (104)