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Prior to administration of CYANOKIT, smoke-inhalation victims should be assessed for the following: Exposure to fire or smoke in an enclosed area Presence of soot around the mouth, nose or oropharynx Altered mental status Although hypotension is highly suggestive of cyanide poisoning, it is only present in a small percentage of cyanide-poisoned smoke inhalation victims

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Additionally, radiation-induced damage is amplified by the generation of reactive oxygen species (ROS), chemically reactive entities capable of oxidizing proteins and lipids and inducing single-strand DNA breaks (indirect effects)

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