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NAD + homeostasis NAD + and NADH The ability of NAD + to accept a hydride ion, forming its reduced form NADH, is instrumental for redox reactions in the cytosol and mitochondria and regulates the activity of dehydrogenases in multiple catabolic processes

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The ER is an industrious place of protein production and transport therefore it was argued that the chaperone proteins must be distinguished from secretory proteins to be exported in order to prevent their release via the secretory pathway