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Arabidopsis pad2-1 accumulates only approximately 20% of the wildtype glutathione level (except for mitochondria), which results from a mutation in the -ECS (GSH1) gene, the enzyme catalyzing the rate-limiting step in glutathione synthesis (Parisy et al

A methodical rotation plan that leaves the same patch unused for 3 to 4 weeks, combined with technique adjustments like injecting over 5 to 10 seconds and holding the needle for 5 seconds, substantially reduces repeated-site irritation

doi: 10.1016/j.immuni.2021.10.009 80 KrawczykCMHolowkaTSunJBlagihJAmielEDeBerardinisRJet al

#6 Skin Flushing (low risk) Temporary skin flushing or redness may occur after injections