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Clinically, melatonin has been reported to reduce the risk of hemorrhagic transformation after tissue plasminogen activator (t-PA) therapy in ischemic stroke (150, 151), suggesting a potential role in improving thrombolytic safety through modulation of BBB permeability

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It is worth noting that in the 5 mg/kg/d treatment group, we did not observe significant changes in serum AMH level and uterine and ovarian organ coefficients, which may be because the exposure dose of this treatment group corresponds to the human safety limit value of DEHP

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