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It is also able to cross the blood-brain barrier (BBB) to reach the subarachnoid space of the leptomeninges, causing meningitis with or without septicemia (van Deuren et al., 2000)

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This protective mechanism is attributed to its interference with Ca 2+ influx-dependent MAPK and AP-1 signaling pathways in HaCaT cells and normal human dermal fibroblasts [58]