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Zinc transporter 8 (ZIP8) (encoded by SLC39A8) is a membrane transporter that has recently been recognized as a manganese transporter whose absence leads to significant manganese deficiency in humans, highlighting the essential role of ZIP8 in regulating manganese homeostasis within the body (Yu and Zhao, 2023[470])

PGC-1 is a key regulator of energy metabolism that synergistically activates many nuclear receptor- and non-nuclear receptor- transcription factors associated with metabolism, such as nuclear respiratory factor (Nrf), mitofusion-1 (Mfn1), and mitochondrial transcription factor A (Tfam) [40]

Magnetic beads were crosslinked to antibody (GLT-1: 0.04 g/l, IgG: 0.02 g/l, Flag: 0.01 g/l) via incubation with 20 M disuccinimidyl suberate