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Crystal structure of a papainE-64 complex

The proposed mechanism involves PCs activating peroxisome proliferator-activated receptor (PPAR) in macrophages, upregulating PPAR target genes (CD36 and ABCG1) and driving the transition from M1 to M2 phenotypes

doi: 10.1016/j.annder.2009.05.002 8

Oxidative stress in liver injury ROS include the free radicals superoxide (O 2 - ) and hydroxyl radical (HO - ) and non-radicals such as hydrogen peroxide (H 2 O 2 )