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[23] [24] [25] Researchers discovered that amantadine and memantine bind to and act as agonists of the 1 receptor (K i = 7.44 M and 2.60 M, respectively) and that activation of the 1 receptor is involved in the central dopaminergic effects of amantadine at therapeutically relevant concentrations

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By using patch-clamp, we first showed that derived neurons exhibited voltage-gated sodium-channel mediated action potentials and received synaptic inputs (Fig

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