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This is suggestive of a prolonged formation of catechin via gut microbial degradation of procyanidins in the colon (Figure 3)

This effect is achieved by the increased ROS formation (prooxidant effect), resulting in caspase 8 cleavage, inhibition of Janus kinase 2 (JAK2), and triggering regulator of apoptosis BAX, known as bcl-2-like protein 4

Moreover, a comprehensive summary of the activation strategies of the GSH system is presented, where we mainly identify several promising herbal monomers, which may provide valuable guidelines for the exploration of new therapeutic approaches