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Multiomics for biomarker discovery Resistance to KRASi is highly heterogeneous, reflecting diverse tumour-intrinsic and microenvironmental adaptations

One of the major risks involves the possibility of abnormal tissue growth, which can lead to irregular cell specialization

doi: 10.3389/fnut.2024.1393673 180 VenturaAPellegriniCCardelliLRoccoTCiciarelliVPerisKet al

Large-scale silencing approaches and functional screenings In the mid 2000s, key technological advances have allowed researchers to tackle CDDP resistance with large-scale functional/empirical approaches, as opposed to high-throughput observational studies followed by low-throughput functional validation (such as the genomic, methylomic, transcriptomic and proteomic approaches described above)