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458 In mice, deletion of IRE1 specifically in myeloid cells reduces cytokine production and protects against inflammatory arthritis, highlighting its role in disease progression

Intriguingly, -1 is not the only Th2 inducing glycoprotein secreted by schistosome eggs, as another glycoprotein, Omega1 (-1), a T2 ribonuclease, has shown to be the primary method by which the eggs induce a Th2 response (181)