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However, SAR425899 was discontinued in phase II clinical trials due to the high occurrence of gastrointestinal adverse events in the subjects [45]

Nature 314 , 9092 (1985)

39 Air Force SBIR Briefing for NRC Staff, June 2013

The longer-term picture is timing-dependent, since started near menopause it appears cognitively safe and may track with lower dementia risk, and the FDA removed the boxed warning, including the probable-dementia language, in 2026