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Human trials have been conducted in Bolivia [19, 20], Italy [21], and the UK [22], while one was multicenter [23]

d , Plasmin concentrations in cell culture supernatant from 4T1 mammary tumour cells overexpressing empty vector, PLGRKT, PLGRKT K147R , and PLGRKT 139-147 (n = 9 individual wells)

Heme oxygenase-1 (HO-1), a cytoprotective enzyme, was upregulated upon treatment with erastin or RSL3 in renal proximal tubule cells, while deletion of HO-1 increased the cellular susceptibility to erastin-induced ferroptosis [37]