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Subsequently, Western Blot (WB) analysis detected a decrease in total P53 expression but an increase in phosphorylated P53 (p-P53) expression in OGD-induced senescent endothelial cells post FOXO4-DRI treatment (Figures 5B,C)

Beyond feeling cold, retatrutide is associated with a broader range of side effects, the majority of which relate to its gastrointestinal activity via GLP-1 receptor agonism