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Simultaneously, long-chain acyl-CoA synthetase 4 (ACSL4) expression decreases, reducing the availability of oxidizable PUFAs, although the exact mechanism underlying this remains unclear

(3179:) MAS proto-oncogene

doi: 10.2522/ptj.20130597 51 JuszczykGMikulskaJKasperekKPietrzakDMrozekWHerbetM

38 MR leads to insufficient SAM, leading to MAT1A/MAT2A transition and the overall DNA hypomethylation, decreased DNA reduction, and genomic instability and abnormal signal transduction are related, including c-MYC overexpression, increased PA synthesis, RAS/ERK, PI-3K upregulated/AKT, and LKB1/AMPK axis