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A yeast two-hybrid (Y2H) screen using cytoplasmic or luminal fragment of TMEM106B for bait and a prey library derived from human adult brain has identified TMEM106C, the endocytic adaptor proteins, AP2M1 and CLTC, and the vacuolar protein sorting proteins, VPS11 and VPS13D as N-terminal TMEM106B-binding proteins, although the functional importance of these interactions remains to be determined [134]

As a detoxifying agent, it can also prove helpful for people suffering from toxicity or fatigue

(1) Ionescu M, Frohman LA (2006) Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog J Clin Endocrinol Metab

In addition, NRF2 also regulates the expression of ferritin subunits to promote free Fe 2+ sequestration, which can inhibit Fe 2+ -dependent free radical generation, and thus reducing the Fe 2+ -mediated toxicity [36]