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Spagnoulo MI, Iorio R, Vegnente A, Guarino A

[Para 37] Cells that ingest foreign particles and invading organisms included neutrophils and monocytes, white blood cells with a single nucleus which describes lymphocytes and macrophages in the blood and the macrophages, which are found in primarily in tissues Macrophages are generally found at the interface of tissues with blood such as the vascular system or cavitary spaces such as the lung, liver (Kupfer cells), joint cavities, and the perivascular microglial cells lining the central nervous system, and kidneys

In situations of intracellular iron overload, Fe2+ engages in a Fenton reaction with HO, giving rise to hydroxyl radicals that bind to polyunsaturated fatty acids, initiating lipid peroxidation and culminating in a marked accumulation of ROS

131 (12), e143691