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This broad regulatory activity includes upregulation of tissue repair genes, collagen synthesis pathways, antioxidant defense systems, and anti-inflammatory signaling networks, alongside simultaneous downregulation of genes associated with tissue destruction, inflammation, and fibrosis

Most patients will develop no or mild symptoms, while some patients may develop hyper-inflammation caused by the production of a large amount of cytokines, known as a cytokine storm, which may lead to fatal pneumonia and acute respiratory distress syndrome (ARDS)

F a = (AUC 0t IMDoseIV)/(AUC 0t IVDoseIM) 100%

Alzheimers disease drug-development pipeline: few candidates, frequent failures