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A reduction in mitochondrial function has also been demonstrated after intense periods of exercise

Giroud-Gerbetant J, Joffraud M, Giner MP, Cercillieux A, Bartova S, Makarov MV, et al

Liver Int 43(7):15071522

It has been hypothesized that many of the senescent changes in body composition and organ function are related to or caused by decreased GH (25), also known as the somatopause