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Other conditions that have been associated with MetS are strongly related with insulin resistance and adiposity, namely, non-alcoholic fatty liver disease (NAFLD), polycystic ovarian syndrome, obstructive sleep apnoea (OSA), hypogonadism, lipodystrophy, and microvascular disease

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1) but the detailed mechanisms of their development have not yet been sufficiently explained, which is one of the main reasons for the lack of effective and safe therapies