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Recent research has identified several adaptive mechanisms through which red blood cells regulate oxygen delivery, including NO-driven changes in membrane deformability, Cys93-dependent S-nitrosylation, adenosine-mediated stimulation of glycolysis and 2,3-BPG production, and the formation of hypoxic memory via degradation of eENT1 (Peng et al., 2019

If you have a B12 deficiency you will be lucky to get the best treatment recommended as it seems to me that GPs pick and choose based on outdated understanding of research and good practice