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In conclusion, PDO models have proven their potential as valuable platforms for drug screening and for recapitulating the tumor microenvironment of individual patients

VCJ was instrumental in revising the manuscript

doi: 10.1517/13543776.2010.525220 46 CorridoniD.PastorelliL.MattioliB.LocoveiS.IshikawaD.ArseneauK

Research also indicates that higher doses, up to 30 g per day, can be used safely for extended periods, including several years, without clinically significant adverse effects