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For example, a study in a medical journal told about a patient with severe anemia and nerve problems

As well, some people may have allergies or medical conditions that do not allow them to be a good candidate to receive vitamin B12 shots, such as kidney problems, low potassium levels, deficiencies in other vitamins such as iron or folic acid, or just an allergy or sensitivity to vitamin B12 itself

While increased cold sensitivity is generally a benign consequence of weight loss, certain presentations warrant medical evaluation to exclude underlying conditions