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The role of the reactive oxygen species and oxidative stress in the pathomechanism of the age-related ocular diseases and other pathologies of the anterior and posterior eye segments in adults

doi: 10.1016/j.molmed.2007.09.002 133 HirookaYNozakiY

High and pathological myopia substantially raise the likelihood of encountering vision-related complications such as glaucoma, retinal detachment, and macular degeneration (54)

We have demonstrated that TDP-43 SUMOylation occurs in response to cellular stress, thus careful characterization of the TDP-43 K408R mice is critical to determine baseline phenotypes without the addition of exogenous stressors