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Non-human primates (NHPs), such as rhesus monkeys, naturally exhibit age related tau and amyloid (A) pathologies, providing models that closely mimic human disease progression (Li et al., 2019)

Caccuri F, Bugatti A, Zani A, De Palma A, Di Silvestre D, Manocha E, et al

Optimization of purification, identification and evaluation of the in vitro anti-tumor activity of polyphenols from Pinus koraiensis pinecones

However, if the goal is to study systemic effectslike tendon repair, muscle recovery, or neuroprotectiona higher dose might be necessary to ensure enough of the compound survives the digestive gauntlet and reaches the bloodstream to circulate throughout the body