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*Correspondence: Tiziana Crepaldi, [email protected] This article was submitted to Signaling, a section of the journal Frontiers in Cell and Developmental Biology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Furthermore, the level of another metabolite, choline, as an integral marker of cell membrane myelin in brain tissue and a precursor of acetylcholine, is significantly elevated in DKD patients

Insulin has important roles in maintaining hippocampus function, and insulin resistance is linked to cognitive deficits due to impaired synaptic plasticity and neurogenesis 50,51,52

It remains unclear whether different subtypes of cirrhosis caused by Metabolic dysfunction-Associated SteatoHepatitis (MASH) have differences in prognosis