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Using in silico design, structureactivity relationships (SARs), chemical optimization, cell-based assays and in vivo experiments, we identified and characterized the first-in-kind small-molecule inhibitors of STX7Munc13-4-dependent endosomal maturation and signaling for use in immune cells that contribute to systemic inflammation

A key challenge limiting the broad use of enantioselective enzymes is the substantial time and effort required to engineer them into fit-for-purpose catalysts, which is often bottlenecked by the speed of chiral screening 5