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Once glutamate is taken by astrocytes, it can be converted to glutamine in an energy-dependent manner via the glial-specific enzyme, glutamine synthetase (GS

In one review paper, the authors state the following: Glutathione (GSH) plays an important role in a multitude of cellular processes, including cell differentiation, proliferation, and apoptosis, and as a result, disturbances in GSH homeostasis are implicated in the etiology and/or progression of a number of human diseases, including cancer, diseases of aging, cystic fibrosis, and cardiovascular, inflammatory, immune, metabolic, and neuro-degenerative diseases

For example, Steinhoff and his colleagues investigated the association of GSTT1 null genotype with both bladder and prostate cancer risk[9]

The pathophysiological consequence of oxidation of the lipids by ROS is lipid peroxidation 59