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Therefore, regulating tumour progression hinges on maintaining ROS below the critical threshold that supports oncogene dependence [23], on the basis of which targeted regulation of SOD activity is regarded as a potential strategy in cancer treatment [24]

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NCBI National Center for Biotechnology Information Search 10GS: HUMAN GLUTATHIONE S-TRANSFERASE P1-1, COMPLEX WITH TER117 PDB ID: 10GS Download MMDB ID: 107035 PDB Deposition Date: 1997/8/14 Updated in MMDB: 2023/08 Experimental Method: x-ray diffraction Resolution: 2.2 Source Organism: Homo sapiens Similar Structures: VAST+ Download sequence data Biological Unit for 10GS: dimeric

45,58,59 A recent study reveals that upon binding to V8 integrin, the flexible membrane-presented latent complex can expose the active domain of the TGF- ligand to its receptors for binding and signaling without the need to release diffusible cytokine