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10.1038/349156a0 116

doi:10.1007/s00406-017-0852-4 Canella C, Bachmann C, Wolfensberger B, Witt CM

the doses were escalated every 4 weeks starting from 0.25 mg to 0.5 mg, 1.0 mg, and 1.7 mg until a dose of 2.4 mg was met and maintained for the remaining 16 weeks