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found that blocking Gln metabolism can enhance tumor-specific immunity by inhibiting the transcription of CSF3 in tumor cells, which decreases the generation and attraction of MDSCs and stimulates the creation of pro-inflammatory TAMs (42)

Suppression of SLC7A11 is also linked to T cell memory-associated enhanced immune responses ( Resistance to Cancer Therapy SLC7A11 overexpression is associated with resistance to immunotherapy, as well as chemo- and radio-resistance, including to drugs such as gemcitabine and cisplatin (84)

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