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DSIP is proposed to interact with components of the MAPK cascade via this mechanism providing a potential molecular basis for its glucocorticoid-related biology, anti-proliferative activity, and stress-protective effects

Infiltration at this point might not be as effective but deep friction massage can be successful if the patient can tolerate it

References: Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis PepT1-Mediated Tripeptide KPV Uptake Reduces Intestinal Inflammation Terminal Signal: Anti-Inflammatory Effects of -Melanocyte-Stimulating Hormone Related Peptides Beyond the Pharmacophore Recent advances in vasoactive intestinal peptide physiology and pathophysiology: focus on the gastrointestinal system Role of vasoactive intestinal peptide in osteoarthritis vasoactive intestinal peptide Vasoactive intestinal peptide: cardiovascular effects Delta sleep-inducing peptide (DSIP): a still unresolved riddle Therapeutic effects of delta-sleep-inducing peptide (DSIP) in patients with chronic, pronounced pain episodes

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