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Abbreviations CyGlySSP: Protein mixed disulfides with cysteinyl glycine CySSHb: S -Cysteinylated hemoglobin CySSP: S -Cysteinylated proteins DTT: Dithiothreitol -GluCySSP: Protein mixed disulfides with -glutamylcysteine GT: -Glutamyl transpeptidase GSH: Glutathione GSSG: Glutathione disulfide GSSP: S -Glutathionylated proteins HbSSG: S -Glutathionylated hemoglobin HcySSP: S -Homocysteinylated proteins HD: Hemodialysis LMM-SH: Low molecular mass thiols mBrB: Monobromobimane NEM: N -Ethylmaleimide NGAL: Neutrophil gelatinase-associated lipocalin PBS: Phosphate-buffered solution PRP: Platelet-rich plasma P-SH: Protein thiol groups RBCs: Red blood cells ROS: Reactive oxygen species RSSP: S -Thiolated proteins t- BOOH: tert -Butyl hydroperoxide TCA: Trichloroacetic acid References Al-Abed Y, VanPatten S, Li H, Lawson JA, FitzGerald GA, Manogue KR, Bucala R (2001) Characterization of a novel hemoglobin-glutathione adduct that is elevated in diabetic patients

Altered NOX-dependent redox stress induced by mutant SOD1 is also thought to be a secondary event associated with neuroinflammation and microgliosis (Boille et al., 2008

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