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While this therapeutic modality exemplifies an exceptional safety architecturewith adverse manifestations predominantly circumscribed to transient and benign gastrointestinal perturbationsthe pursuit of optimized clinical outcomes reveals substantial interindividual heterogeneity in therapeutic responsiveness

Moreover, paclitaxel has also been reported to induce neurotoxicity, primarily by affecting neural stem cells and progenitor cells in the hippocampus, which leads to impaired spatial memory (Huehnchen et al., 2017)

In the early stages of killing, they directly lyse cancer cells through the release of perforin and granzymes, while in later stages, they induce apoptosis via FasL or TRAIL expression, independent of prior antigen priming [177]

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