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In the acute phase of ischemia, which is characterized by anoxic depolarization and a massive increase in [Ca 2+ ] i mediated by both Ca 2+ influx and Ca 2+ -induced Ca 2+ release from intracellular stores, the vesicular release from presynaptic terminals further adds to the glutamate elevation

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Baseline: CBC, B12, folate, iron studies Repeat B12 levels 1 month after loading dose Annual checks for chronic therapy Monitor potassium during initial treatment Neurological exams for neuropathic symptoms B12 injections can "mask" megaloblastic anemia from folate deficiency while allowing neurological damage to progress

191 Ferrostatins can further enhance the protective effect of necroptosis inhibitors on renal I/R injury