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Furthermore, stochastic kinetic models quantify the intrinsic efficiency limitations of repair pathways, such as the competition between repair and lesion bypass in transcription-coupled repair (73)

Inhibitors targeting key enzymes of fatty acid synthesis, such as ACC inhibitors and FASN inhibitors, have already achieved significant therapeutic efficacy in a variety of tumors [205]

Shifting from the single to the multitarget paradigm in drug discovery

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