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13 C-labeled R5P was detected by LC-MS/MS

Preclinical studies further demonstrate that combining PPR with donepezil enhances therapeutic efficacy in AD rat models by improving synaptic plasticity, reducing oxidative stress, and ameliorating histopathological outcomes (36)

Comment: Several commenters cautioned CMS to avoid defaulting to extensions in cases where broader relief is warranted and ensure reporting extensions are not disproportionately utilized in place of exceptions