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It normally undergoes glucuronidation and sulfation to the corresponding conjugates, which together comprise 95% of the total excreted metabolites

10.1128/CMR.16.3.497-516.2003 113

And finally, dont touch spironolactone with a ten-foot pole

proposed a negative correlation between omega-3 fatty acid intake and positivity for anti-cyclic citrullinated peptide (anti-CCP) antibodies among participants at risk of future RA