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Reddy and Comai, 2012)

GHRP-6 combined with a GHRH analogue produces GH elevation that is dramatically, synergistically greater than either compound alone

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Triggered by ghrelin receptor activation Can lead to unintended fat gain if unmanaged Typically subsides slightly over time MK-677 significantly increased appetite due to its ghrelin-mimetic properties, making it a double-edged sword for body composition. Patel et al., The Journal of Clinical Endocrinology & Metabolism 2