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Sterols block binding of COPII proteins to SCAP, thereby controlling SCAP sorting in ER

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Following structural damage and functional impairment of the muscle tissue, myofibrillar rupture and extravasation of intracellular proteins such as myoglobin, creatine kinase (CK), and lactate dehydrogenase (LDH), into the extracellular medium, trigger the local inflammatory response [47, 50,51,52]

In oxidative phosphorylation, molecular oxygen can receive electrons from complex IV that are moving down the electron transport chain (ETC) and are then transferred to produce water