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PMC 11754111

Even upon reaching the tumor site, the nanocarriers size and surface properties can impede deep tissue penetration, while stimulus-responsive release mechanisms may prove unreliable in the complex in vivo milieu, leading to suboptimal or uncontrolled drug release [211]

Its job is to allow the right things through, like nutrients, water, certain small molecules, while keeping out everything that doesnt belong in systemic circulation

TPR5G (AT5G02590, 981 bp) or the TPR domain (318 bp, from 700 to 1017) of TPR14 (AT5G65160, 1,782 bp) was amplified via PCR from Col-0 cDNA using the primers in Supplementary Table 1 and introduced into pMDC32 -p2x35S :: FLAG to obtain pMDC32 -p2x35S :: TPR5G-FLAG or pMDC32 -p2x35S :: TPR14 TPR -FLAG