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PLoS Genet 12:e1005788 An JH, Blackwell TK (2003) SKN-1 links C

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Fibroblasts (CAFs) constitute the largest group of nonimmune cells in the TME, and there is increasing evidence that CAFs can regulate glutamine levels in the TME and thus generate energy to promote the tricarboxylic acid cycle (TCA) cycle and supply energy for cancer cell growth [12]