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Since the primary source of ROS is mitochondria, mitochondrial dysfunction should be the initial step in an explosive increase in ROS

Clinical and animal studies have confirmed that the tumor necrosis factor- (TNF-) inhibitor pentoxifylline treats AH and exerts anti-inflammatory effects by inhibiting phosphodiesterase

Hepatic mitochondria provide a hub for liver metabolic homeostasis by uniquely integrating or coordinating multiple metabolic pathways of carbohydrate, lipid, cholesterol, bile acid, and amino acids for energy homeostasis and by keeping the balance of reducing equivalents and intermediary metabolites in the liver and whole body via mitochondria-cytoplasm shuttles

Overall incidence rate per 1000 person-years for MALO, death and MACE was 6.3, 4.9, and 1.8, respectively