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To further investigate how ferroptosis could affect glia cells in AD, we looked at the difference in expression of ferroptosis-related genes in microglia between control and AD brains containing only amyloid- plaques in the occipital cortex (OC) and both amyloid- and tau pathology in the occipitotemporal cortex (OTC) ( p -value below 0.05 was used to determine the significance (Table 2)

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Notably, maintaining an optimal balance of antioxidants, including glutathione, may be key in managing inflammation and disease progression in patients with IBD