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Description

It is now thought that oxidative stress is implicated in the pathogenesis of several diseases and conditions, from aging to inflammation and carcinogenesis, if not as a primary cause of disease at least as an aggravating mechanism

Inhibition of key ferroptosis regulators like acyl coenzyme ACSL4, GPX4, and Nrf2 may lead to unintended consequences, including disruptions to cellular homeostasis, thereby posing potential risks to therapeutic safety