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Conclusions Over 5 years, there are savings of $14.2 million to the health care system from switching to vitamin B12 oral supplements

While the RNI for maintenance is only 1.5 g daily, therapeutic oral doses typically range from: 50-150 g daily for mild deficiency prevention in at-risk groups 1,000-2,000 g daily for treating confirmed deficiency without malabsorption Some formulations contain up to 5,000 g, though there is no proven additional benefit over 1,000-2,000 g for most patients The reason for this dosage discrepancy lies in absorption efficiency

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If gelling keeps happening despite careful room-temperature handling, slow wall injection, and gentle mixing, then a revised solvent system is a reasonable troubleshooting step, as noted earlier