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Rather than measuring B12 directly, the MR used 8 genetic variants (SNPs) known to raise B12 levels as a proxy for lifelong B12 levels

A randomized, controlled trial involving 76 patients with medication-refractory essential tremor showed that transcranial FUS thalamotomy significantly reduced hand tremor at 3 months, and the effect persisted during the 12-month study period [108]